SNAP Trial

This is a substudy within the SNAP trial to test the prognostic significance of Staphylococcus aureus bacteriuria.

Bacteriuria refers to the presence of bacteria in urine.
Among patients with S. aureus bacteremia (SAB), up to 39% will have concominant positive urine culture for S. aureus
Current related studies have conflicting data, suggesting that bacteriuria may be a marker of endocarditis, bone and joint infections, and a predictor of complications and poor outcome of SAB.

What will the substudy involve - more information

All patients included in both the SNAP RCT and registry that have available mortality data will be included in this retrospective analysis.
The co-primary outcomes include 90-day all-cause mortality and any deep-seated infection (defined as endocarditis or bone and joint) indentified at any time of SAB.
Independent variables will include demographics, infection characteristics, including randomization arm, as well as urine culture status - positive or negative.
We will also perform a comparison between patients who had or did not have urine culture collection in order to evaluate the applicability of our results for any SAB treatment.

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Where will substudy data be collected and stores?

No additional substudy-specific data will be collected.

Microbiological data, as documented in the SNAP CRF will be retrospectively analyzed.

Where will substudy isolates be collected and stores?

No additional isolates will be collected as part of this substudy.

Substudies in Progress

SNAP Trial

SABSI

Profiling the genetic and epigenetic determinants that predispose to severe manifestations of Staphylococcus aureus bacteremia

All Interested

Substudy in Progress

cfDNA

Cell-free DNA is a Versatile Analyte to Monitor Complications and Guide Treatment Duration in Staphylococcus aureus Bacteremia

Any interested

Substudy in Progress

SABSI-Outcomes

Derivation and Validation of Phenotypes of Staphylococcus aureus bloodstream infection, with Correlation with Outcome.

Any Interested

Substudy in Progress

SNAP-SEQ

Pilot study for real-time sequencing of Staphylococcus aureus bloodstream isolates

Any Interested

Substudy in Progress

PENFAST

Using a validated penicillin allergy risk prediction tool (Pen-FAST) in patients with a low risk penicillin allergy

Any Interested

Substudy in Progress

Pharmacogenomics

Immunopathogenesis and pharmacogenomics of severe antibiotic hypersensitivity

Australia

Substudy in Progress

Bacteriuria

What will the substudy involve - more information

Where will substudy data be collected and stores?

Where will substudy isolates be collected and stores?

Substudies in Progress

SABSI

cfDNA

SABSI-Outcomes

SNAP-SEQ

PENFAST

Pharmacogenomics

Index

Further Info

Policy